Adapun pembelahan sel dibedakan menjadi dua macam, yaitu Pembelahan Mitosis dan Pembelahan Meiosis. Pembelahan Mitosis adalah peristiwa pembelahan sel yang terjadi pada selsel somatis (sel tubuh). Pembelahan ini menghasilkan dua sel anak yang memiliki genotipe sama dan identik dengan sel induknya. Dua sel anak yang dihasilkan bersifat diploid. Meiosis occurs only at the final division of gamete maturation. 3- Mitosis occurs as a single one-step process. Meiosis can be considered as two cell divisions known as meiosis I and meiosis II, each of which can be considered as having prophase, metaphase, anaphase and telophase stages as in mitosis.
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Manual labour or manual work is physical work done by people, most especially in contrast to Thus there is a partial but significant correlation between manual labour and unskilled or semiskilled workers. Difficult because not all social status differences and wealth differences are unfair; meritocracy is a part of real life,translation and definition 'Non-manual workers', Dictionary English-English online the jobs or working practices for manual workers and non-manual workers. DISTINCTION BETWEEN MANUAL AND NON-MANUAL WORKERS A.
THE MECHANISM OF HUMAN OVARIAN PRIMORDIAL FOLLICULAR ASSEMBLY AND DEVELOPMENTYosep Sutandar(1*), Suryono S.I. Santoso(2) (1) Gadjah Mada University (2) Division of Reproductive Medicine, Department of Obstetrics and Gynecology Faculty of Medicine University of Indonesia, National Center Hospital Dr. Cipto Mangunkusumo (*) Corresponding Author Abstract
Yosep Sutandar1, Suryono S.I. Santoso2
ABSTRAK
Latar Belakang: Pembentukan dan perkembangan folikel primordial merupakan aspek yang penting pada sistemreproduksi perempuan, tetapi mekanismenya masih kurang dipahami. Pembentukan folikel primordial adalah proses dimana folikel primordial ovarium terbentuk. Sebuah folikel primordial terdiri dari oosit yang berada di profase jika pembelahan meiosis yang pertama dan dikelilingi oleh satu lapisan sel-sel pra-granulosa. Proses ini secara langsung memengaruhi jumlah oosit yang tersedia bagi seorang wanita sepanjang usia reproduksinya. Kelainan pada perkembangan folikel primordial menyebabkan sejumlah patofisiologi, tetapi mekanisme terjadi masih belum dapat dipahami.
Tujuan: Untuk memahami mekanisme perakitan dan pengembangan manusia ovarium folikel primordial.
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Metode: Review artikel
Kesimpulan: Pembentukan folikel primordial adalah proses dimana folikel primordial ovarium terbentuk.Pembentukan folikel primordial dihambat oleh progesteron untuk tingkat yang lebih besar daripada estrogen, namun kedua steroid tersebut menghambat proses pembentukan. Proses apoptosis oosit secara acak dalam sarang oosit diperlukan untuk pembentukan folikel dan tumor necrosis factor-alpha (TNF) tampaknya juga terlibat dalam proses ini. Baru-baru ini, penelitian telah menunjukkan bahwa KL, basic fibroblast growth factor (bFGF), leukemia inhibitory factor (LIF), KGF, dan bone morphogenic protein -4 (BMP-4) dapat memengaruhi perkembangan folikel primordial.
Kata kunci: folikel, primordial, pembentukan, perkembangan.
ABSTRACT
Backgrounds: primordial follicle assembly and development is a critical aspect of female reproduction, but poorlyunderstood process on mechanistic level. Primordial follicle assembly is the process by which ovarian primordial follicles are formed. A primordial follicle is composed of an oocyte arrested in prophase if the first meiotic division and surrounded by a single layer of pre-granulosa cells. These processes directly affect the number of oocytes available to a female throughout her reproductive life. Abnormalities in primordial follicle development lead to a number of pathologies, but the mechanism are poorly understood.
Objective: To understand the mechanism of assembly and development of human ovarian primordial follicle.
Method: Literature review
Conclusion: Primordial follicle assembly is the process by which ovarian primordial follicles are formed. Primordialfollicle assembly was inhibited by progesterone to a greater degree than estrogen, but both steroids inhibited the assembly process. The apoptosis of random oocytes in the oocyte nests is required for primordial follicle assembly and tumor necrosis factor-alpha (TNFβ) appears to be involved in this process. More recently, studies have demonstrated that KL, basic fibroblast growth factor (bFGF), leukemia inhibitory factor (LIF), KGF, and bone morphogenic protein-4 (BMP-4) can influence primordial follicle development.
Key words: follicle, primordial, assembly, development
1,2 Division of Reproductive Medicine, Department of Obstetrics and Gynecology Faculty of Medicine University of Indonesia, National Center Hospital Dr. Cipto Mangunkusumo Telephone: 081294037518. Email: [email protected]
DOI: https://doi.org/10.22146/jkr.7126 Article MetricsAbstract views : 2309 | views : 616Refbacks
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